Gec1-κ Opioid Receptor Binding Involves Hydrophobic Interactions: Gec1 Has Chaperone-like Effect
نویسندگان
چکیده
GEC1-κ OPIOID RECEPTOR BINDING INVOLVES HYDROPHOBIC INTERACTIONS: GEC1 HAS CHAPERONE-LIKE EFFECT Yong Chen, Chongguang Chen, Evangelia Kotsikorou, Diane L. Lynch, Patricia H. Reggio and Lee-Yuan Liu-Chen 1 Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA 2 Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, NC, USA Running title: GEC1-KOPR interaction Address corresbondence to: Dr. Lee-Yuan Liu-Chen, Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA Tel: 1-215-707-4188; Fax: 1-215-707-7068; E-Mail: [email protected]
منابع مشابه
Effects of C-terminal Modifications of Gec1 and Gabarap, Two Microtubules-associated Proteins, on Kappa Opioid Receptor Expression
MICROTUBULES-ASSOCIATED PROTEINS, ON KAPPA OPIOID RECEPTOR EXPRESSION Chongguang Chen, Yulin Wang, Peng Huang and Lee-Yuan Liu-Chen Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA Running head: GEC1-KOPR interaction Address correspondence to: Dr. Lee-Yuan Liu-Chen, Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, ...
متن کاملThe role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.
GABARAPL1/GEC1 is an early estrogen-induced gene which encodes a protein highly conserved from C. elegans to humans. Overexpressed GABARAPL1 interacts with GABAA or kappa opioid receptors, associates with autophagic vesicles, and inhibits breast cancer cell proliferation. However, the function of endogenous GABARAPL1 has not been extensively studied. We hypothesized that GABARAPL1 is required f...
متن کاملMolecular docking study of Papaver alkaloids to some alkaloid receptors
Background and objectives: More than 40 different alkaloids have been obtained from opium the most important of which are morphine, codeine, papaverine, noscapine and tabaine. Opioid alkaloids produce analgesia by affecting areas of the brain that have peptides with pharmacological pseudo-opioid properties. These alkaloids show important effects on some intracellular peptides l...
متن کاملThermodynamic Analysis for Cationic Surfactants Binding to Bovine Serum Albumin
In the present study, the binding isotherms for interaction of a homologous series of n-alkyltrimethyl ammonium bromides with bovine serum albumin (BSA) have been analyzed on basis of intrinsic thermodynamic quantities. In this regards, the intrinsic Gibbs free energy of binding, AGb(i,)„ has been estimated at various surfactant concentrations and its trend of variation for both binding sets ha...
متن کاملSpecific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1
Macroautophagy is a highly conserved cellular degradation process, regulated by autophagy-related (atg) factors, in which a double membrane autophagosome engulfs cytoplasmic components to target them for degradation. In yeast, the Atg8 protein is indispensable for autophagosome formation. In mammals, this is complicated by the presence of six Atg8 homologues grouped into the GABARAP and MAP1LC3...
متن کامل